POTENTIAL OF BIOACTIVE COMPOUNDS, STANDARDIZATION OF GACP-WHO CULTIVATION, AND CHALLENGES OF DOWNSTREAM HERBAL PLANTS IN INDONESIA: A LITERATURE REVIEW
Keywords:
Herbal plants, bioactive compounds, cultivation, WHO GACP, literature reviewAbstract
Indonesia has great potential for developing herbal plants as raw materials for traditional medicine and health products, but the industry still faces challenges in cultivation, standardization, research, and processing. This literature review examines the bioactive compounds and cultivation practices of ginger (Zingiber officinale), turmeric (Curcuma longa), temulawak (Curcuma xanthorrhiza), sambiloto (Andrographis paniculata), and gotu gotu (Centella asiatica), based on WHO Good Agricultural and Collection Practices (GACP). The findings show that these plants contain bioactive compounds such as gingerol, curcumin, xanthorrhizol, andrographolide, and asiaticoside, which have various potential biological activities. However, limited technology, climate change, lack of standardization, and dependence on imported materials remain major challenges. Strengthening research, cultivation quality, standardization, and processing technology is essential to support the sustainable development of Indonesia’s herbal industry.
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References
Ayustaningwarno, F., Anjani, G., Ayu, M., & Fogliano, V. (2024). A critical review of Ginger's (Zingiber officinale) antioxidant, anti-inflammatory, and immunomodulatory activities. Frontiers in Nutrition, 11, 1364836. https://doi.org/10.3389/fnut.2024.1364836
Food and Drug Supervisory Agency of the Republic of Indonesia. (2026). Data on licensing of herbal products, standardized herbal medicines (OHT), and phytopharmaceuticals as of February 2026. BPOM RI.
Bylka, W., Znajdek-Awiżeń, P., Studzińska-Sroka, E., & Dańczak-Pazdrowska, A. (2014). Centella asiatica in dermatology: An overview. Phytotherapy Research, 28(8), 1117–1124. https://doi.org/10.1002/ptr.5110
Devaraj, S., Esfahani, A. S., Ismail, S., Ramanathan, S., & Yam, M. F. (2010). Evaluation of the antinociceptive activity and acute oral toxicity of standardized ethanolic extract of the rhizome of Curcuma xanthorrhiza Roxb. Molecules, 15(4), 2925–2934. https://doi.org/10.3390/molecules15042925
Directorate General of Horticulture, Ministry of Agriculture of the Republic of Indonesia. (2024). Government Agency Performance Accountability Report (LAKIP) of the Directorate of Vegetables and Medicinal Plants in 2024. Ministry of Agriculture.
Dugasani, S., Pichika, M. R., Nadarajah, V. D., Balijepalli, M. K., Tandra, S., & Korlakunta, J. N. (2010). Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. Journal of Ethnopharmacology, 127(2), 515–520. https://doi.org/10.1016/j.jep.2009.10.004
Euromonitor International. (2020). Forecast of national herbal medicine and herbal medicine sales forecast in Indonesia 2020–2025 [Quoted in Aditama Putra, Journal of Justice Breeding]. Euromonitor International.
Handoko, L. T. (2024, June 3). BRIN identifies 30,000 biodiversity species, Indonesia can create drug sovereignty [Interview]. Voice of West Kalimantan. https://www.suarakalbar.co.id/2024/06/brin-identifikasi-30-000-spesies-biodiversitas-indonesia-bisa-ciptakan-kedaulatan-obat/
Hewlings, S. J., & Kalman, D. S. (2017). Curcumin: A review of its effects on human health. Foods, 6(10), 92. https://doi.org/10.3390/foods6100092
Ikrar, T. (2025, December 6). The development of herbal medicine in Indonesia, lessons and challenges [Public lecture]. Faculty of Medicine, Sebelas Maret University, Surakarta. https://uns.ac.id/id/kerja-sama-uns/kepala-bpom-gandeng-uns-untuk-optimalkan-potensi-kekayaan-alam-dengan-pengembangan-obat-bahan-alam.html
Kocaadam, B., & Şanlier, N. (2017). Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Critical Reviews in Food Science and Nutrition, 57(13), 2889–2895. https://doi.org/10.1080/10408398.2015.1077195
Kompas. (2022, August 3). The threat of the climate crisis to the diversity of Indonesian medicinal plants. Kompas.id. https://www.kompas.id/artikel/ancaman-krisis-iklim-terhadap-keberagaman-tanaman-obat-indonesia
Naik, S. R., & Hule, A. (2009). Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata. Planta Medica, 75(8), 785–791. https://doi.org/10.1055/s-0029-1185398
Rahmat, E., Kang, Y. H., & Amin, B. (2021). Javanese turmeric (Curcuma xanthorrhiza Roxb.): Ethnobotany, phytochemistry, biotechnology, and pharmacological activities. Evidence-Based Complementary and Alternative Medicine, 2021, 9960813. https://doi.org/10.1155/2021/9960813
Shukla, A., Rasik, A. M., Jain, G. K., Shankar, R., Kulshrestha, D. K., & Dhawan, B. N. (1999). In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. Journal of Ethnopharmacology, 65(1), 1–11. https://doi.org/10.1016/S0378-8741(98)00141-X
Wang, W., Wang, J., Dong, S. F., Liu, Q., Wang, Z., & Liu, Z. (2010). Immunomodulatory activity of andrographolide on macrophage activation and specific antibody response. Acta Pharmacologica Sinica, 31(2), 191–201. https://doi.org/10.1038/aps.2009.205
World Health Organization. (2003). WHO guidelines on good agricultural and collection practices (GACP) for medicinal plants. World Health Organization. https://www.who.int/publications/i/item/9241546271
Zed, M. (2008). Literature research methods (Cet. 1). Indonesian Torch Foundation.



